SRBP2_HUMAN

Source: PM19886704
PM23856902
Marked as 'Integral membrane protein'
Confidence: low (only semi-automatic identification from reviews) Search PubMed for
(RBC AND this entry)
Gene names: SREBF2 , BHLHD2, SREBP2
Protein names and data: SRBP2_HUMAN , Sterol regulatory element-binding protein 2; SREBP-2 , Class D basic helix-loop-helix protein 2; bHLHd2; Sterol regulatory element-binding transcription factor 2; Processed sterol regulatory element-binding protein 2 Lenght: 1141 a.a.
Mass: 123688 Da
fasta formatted sequence
Function: Transcriptional activator required for lipid homeostasis. Regulates transcription of the LDL receptor gene as well as the cholesterol and to a lesser degree the fatty acid synthesis pathway (By similarity). Binds the sterol regulatory element 1 (SRE-1) (5'-ATCACCCCAC-3') found in the flanking region of the LDRL and HMG-CoA synthase genes.
Cellular location: Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Cytoplasmic vesicle, COPII-coated vesicle membrane; Multi-pass membrane protein. Note=Moves from the endoplasmic reticulum to the Golgi in the absence of sterols. Processed sterol regulatory element-binding protein 2: Nucleus.
Tissue specificity: Ubiquitously expressed in adult and fetal tissues.

Genetic variants

Database cross-references

UniProt: Q12772
Ensembl: ENST00000361204
MIM: 600481
neXtProt: NX_Q12772
Antibodypedia: Q12772 (may not find the protein thus also not any antibody)
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