SRBS1_HUMAN

Source: PM19886704
PM23856902
Marked as 'Membrane associated protein'
Confidence: low (only semi-automatic identification from reviews) Search PubMed for
(RBC AND this entry)
Gene names: SORBS1 , KIAA0894, KIAA1296, SH3D5
Protein names and data: SRBS1_HUMAN , Sorbin and SH3 domain-containing protein 1 , Ponsin; SH3 domain protein 5; SH3P12; c-Cbl-associated protein; CAP Lenght: 1292 a.a.
Mass: 142513 Da
fasta formatted sequence
Function: Plays a role in tyrosine phosphorylation of CBL by linking CBL to the insulin receptor. Required for insulin- stimulated glucose transport. Involved in formation of actin stress fibers and focal adhesions (By similarity).
Cellular location: Cell junction, adherens junction. Cell membrane. Cytoplasm, cytoskeleton. Cell junction, focal adhesion. Nucleus (By similarity). Nucleus matrix (By similarity). Note=Colocalizes with the Ten-1 ICD form of TENM1 in the nucleus (By similarity). Colocalizes with actin stress fibers. Also detected at the plasma membrane and in neuronal intranuclear inclusions. Colocalized with PXN at focal adhesions during myogenic differentiation.
Tissue specificity: Detected in skeletal muscle (at protein level). Widely expressed with highest levels in heart and skeletal muscle.

Genetic variants

Database cross-references

UniProt: Q9BX66
Ensembl: ENST00000277982
Ensembl: ENST00000306402
Ensembl: ENST00000347291
Ensembl: ENST00000353505
Ensembl: ENST00000354106
Ensembl: ENST00000361941
Ensembl: ENST00000371227
Ensembl: ENST00000371239
Ensembl: ENST00000371241
Ensembl: ENST00000371245
Ensembl: ENST00000371246
Ensembl: ENST00000371247
Ensembl: ENST00000371249
Ensembl: ENST00000393949
Ensembl: ENST00000607232
MIM: 605264
neXtProt: NX_Q9BX66
Antibodypedia: Q9BX66 (may not find the protein thus also not any antibody)
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