SRC8_HUMAN

Source: PM19886704
PM23856902
Marked as 'Membrane associated protein'
Confidence: low (only semi-automatic identification from reviews) Search PubMed for
(RBC AND this entry)
Gene names: CTTN , EMS1
Protein names and data: SRC8_HUMAN , Src substrate cortactin , Amplaxin; Oncogene EMS1 Lenght: 550 a.a.
Mass: 61586 Da
fasta formatted sequence
Function: Contributes to the organization of the actin cytoskeleton and cell structure. In complex with ABL1 and MYLK regulates cortical actin-based cytoskeletal rearrangement critical to sphingosine 1-phosphate (S1P)-mediated endothelial cell (EC) barrier enhancement. Plays a role in the regulation of cell migration. Plays a role in the invasiveness of cancer cells, and the formation of metastases.
Cellular location: Cytoplasm, cytoskeleton. Cell projection, lamellipodium. Cell projection, ruffle. Cell projection, dendrite (By similarity). Cell projection, dendritic spine (By similarity). Note=Associated with membrane ruffles and lamellipodia. In the presence of CTTNBP2NL, colocalizes with stress fibers (By similarity). In the presence of CTTNBP2, localizes at the cell cortex (By similarity). In response to neuronal activation by glutamate, redistributes from dendritic spines to the dendritic shaft (By similarity).

Database cross-references

UniProt: Q14247
Ensembl: ENST00000301843
Ensembl: ENST00000346329
Ensembl: ENST00000376561
MIM: 164765
neXtProt: NX_Q14247
Antibodypedia: Q14247 (may not find the protein thus also not any antibody)
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