STAB2_HUMAN

Source: PM23856902
Marked as 'Integral membrane protein'
Confidence: low (only semi-automatic identification from reviews) Search PubMed for
(RBC AND this entry)
Gene names: STAB2 , FEEL2, FELL, FEX2, HARE
Protein names and data: STAB2_HUMAN , Stabilin-2 , FAS1 EGF-like and X-link domain-containing adhesion molecule 2; Fasciclin, EGF-like, laminin-type EGF-like and link domain-containing scavenger receptor 2; FEEL-2; Hyaluronan receptor for endocytosis; 190 kDa form stabilin-2; 190 kDa hyaluronan receptor for endocytosis; Flags: Precursor Lenght: 2551 a.a.
Mass: 276988 Da
fasta formatted sequence
Function: Phosphatidylserine receptor that enhances the engulfment of apoptotic cells. Hyaluronan receptor that binds to and mediates endocytosis of hyaluronic acid (HA). Acts also, in different species, as a primary systemic scavenger receptor for heparin (Hep), chondroitin sulfate (CS), dermatan sulfate (DS), nonglycosaminoglycan (GAG), acetylated low-density lipoprotein (AcLDL), pro-collagen propeptides and advanced glycation end products (AGE). May serve to maintain tissue integrity by supporting extracellular matrix turnover or it may contribute to maintaining fluidity of bodily liquids by resorption of hyaluronan. Counter receptor which plays an important role in lymphocyte recruitment in the hepatic vasculature. Binds to both Gram-positive and Gram-negative bacteria and may play a role in defense against bacterial infection. The proteolytically processed 190 kDa form also functions as an endocytosis receptor for heparin internalisation as well as HA and CS.
Cellular location: Cell membrane; Single-pass type I membrane protein. Cytoplasm. Note=Only a small amount appears to be present at the cell surface.
Tissue specificity: Highly expressed in sinusoidal endothelial cells of liver, spleen and lymph nodes. Also expressed in non SEC- cells such as HMDMs (monocyte-derivedmacrophages), HAMs (T-cell leukemia virus type 1-associated myelopathy), and several macrophage cell line.

Genetic variants

Database cross-references

UniProt: Q8WWQ8
Ensembl: ENST00000388887
MIM: 608561
neXtProt: NX_Q8WWQ8
Antibodypedia: Q8WWQ8 (may not find the protein thus also not any antibody)
Local full text data: click here

Users' comments

Login to add a comment.