STABP_HUMAN

Source: PM19886704
PM23856902
Marked as 'Membrane associated protein'
Confidence: low (only semi-automatic identification from reviews) Search PubMed for
(RBC AND this entry)

Gene names: STAMBP , AMSH
Protein names and data: STABP_HUMAN , STAM-binding protein; 3.4.19.- , Associated molecule with the SH3 domain of STAM; Endosome-associated ubiquitin isopeptidase Lenght: 424 a.a.
Mass: 48077 Da
fasta formatted sequence

Function: Zinc metalloprotease that specifically cleaves 'Lys-63'- linked polyubiquitin chains. Does not cleave 'Lys-48'-linked polyubiquitin chains (By similarity). Plays a role in signal transduction for cell growth and MYC induction mediated by IL-2 and GM-CSF. Potentiates BMP (bone morphogenetic protein) signaling by antagonizing the inhibitory action of SMAD6 and SMAD7. Has a key role in regulation of cell surface receptor-mediated endocytosis and ubiquitin-dependent sorting of receptors to lysosomes. Endosomal localization of STAMBP is required for efficient EGFR degradation but not for its internalization (By similarity). Involved in the negative regulation of PI3K-AKT-mTOR and RAS-MAP signaling pathways.
Disease:
Cellular location: Nucleus. Membrane; Peripheral membrane protein. Cytoplasm. Early endosome.
Tissue specificity: Ubiquitously expressed.

Genetic variants

Database cross-references

UniProt: O95630
Ensembl: ENST00000339566
Ensembl: ENST00000394070
Ensembl: ENST00000394073
Ensembl: ENST00000409707
MIM: 606247
MIM: 614261
neXtProt: NX_O95630
Antibodypedia: O95630 (may not find the protein thus also not any antibody)
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