STAM1_HUMAN

Source: PM19886704
PM23856902
Marked as 'Membrane associated protein'
Confidence: low (only semi-automatic identification from reviews) Search PubMed for
(RBC AND this entry)
Gene names: STAM , STAM1
Protein names and data: STAM1_HUMAN , Signal transducing adapter molecule 1; STAM-1 Lenght: 540 a.a.
Mass: 59180 Da
fasta formatted sequence
Function: Involved in intracellular signal transduction mediated by cytokines and growth factors. Upon IL-2 and GM-CSL stimulation, it plays a role in signaling leading to DNA synthesis and MYC induction. May also play a role in T-cell development. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with HGS (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes.
Cellular location: Cytoplasm (Probable). Early endosome membrane; Peripheral membrane protein; Cytoplasmic side (Probable).
Tissue specificity: Ubiquitously expressed.

Genetic variants

Database cross-references

UniProt: Q92783
Ensembl: ENST00000377524
Ensembl: ENST00000565101
MIM: 601899
neXtProt: NX_Q92783
Antibodypedia: Q92783 (may not find the protein thus also not any antibody)
Local full text data: click here

Users' comments

Login to add a comment.