STEA3_HUMAN

Source: PM23856902
Marked as 'Integral membrane protein'
Confidence: low (only semi-automatic identification from reviews) Search PubMed for
(RBC AND this entry)
Gene names: STEAP3 , TSAP6
Protein names and data: STEA3_HUMAN , Metalloreductase STEAP3; 1.16.1.- , Dudulin-2; Six-transmembrane epithelial antigen of prostate 3; Tumor suppressor-activated pathway protein 6; hTSAP6; pHyde; hpHyde Lenght: 488 a.a.
Mass: 54601 Da
fasta formatted sequence
Function: Endosomal ferrireductase required for efficient transferrin-dependent iron uptake in erythroid cells. Participates in erythroid iron homeostasis by reducing Fe(3+) to Fe(2+). Can also reduce of Cu(2+) to Cu(1+), suggesting that it participates in copper homeostasis. Uses NADP(+) as acceptor. May play a role downstream of p53/TP53 to interface apoptosis and cell cycle progression. Indirectly involved in exosome secretion by facilitating the secretion of proteins such as TCTP.
Disease:
Cellular location: Endosome membrane; Multi-pass membrane protein (By similarity). Note=Localizes to vesicular-like structures at the plasma membrane and around the nucleus.
Tissue specificity: Expressed in adult bone marrow, placenta, liver, skeletal muscle and pancreas. Down-regulated in hepatocellular carcinoma.

Genetic variants

Database cross-references

UniProt: Q658P3
Ensembl: ENST00000354888
Ensembl: ENST00000393106
Ensembl: ENST00000393107
Ensembl: ENST00000393108
Ensembl: ENST00000393110
Ensembl: ENST00000425223
MIM: 609671
MIM: 615234
neXtProt: NX_Q658P3
Antibodypedia: Q658P3 (may not find the protein thus also not any antibody)
Local full text data: click here

Users' comments

Login to add a comment.