RBCC Red Blood Cell Collection

STK10_HUMAN

Source: PM19886704
PM23856902
Marked as 'Membrane associated protein'
Confidence: low (only semi-automatic identification from reviews) Search PubMed for
(RBC AND this entry)
Gene names: STK10 , LOK
Protein names and data: STK10_HUMAN , Serine/threonine-protein kinase 10; 2.7.11.1 , Lymphocyte-oriented kinase Lenght: 968 a.a.
Mass: 112135 Da
fasta formatted sequence
Function: Serine/threonine-protein kinase involved in regulation of lymphocyte migration. Phosphorylates MSN, and possibly PLK1. Involved in regulation of lymphocyte migration by mediating phosphorylation of ERM proteins such as MSN. Acts as a negative regulator of MAP3K1/MEKK1. May also act as a cell cycle regulator by acting as a polo kinase kinase: mediates phosphorylation of PLK1 in vitro; however such data require additional evidences in vivo.
Catalytic activity: ATP + a protein = ADP + a phosphoprotein.
Disease: ( OMIM: 273300 603919 ) Testicular germ cell tumor (TGCT) [MIM:273300]: A common malignancy in males representing 95% of all testicular neoplasms. TGCTs have various pathologic subtypes including: unclassified intratubular germ cell neoplasia, seminoma (including cases with syncytiotrophoblastic cells), spermatocytic seminoma, embryonal carcinoma, yolk sac tumor, choriocarcinoma, and teratoma. Note=The disease may be caused by mutations affecting the gene represented in this entry.
Cellular location: Cell membrane; Peripheral membrane protein.
Tissue specificity: Highly expressed in rapidly proliferating tissues (spleen, placenta, and peripheral blood leukocytes). Also expressed in brain, heart, skeletal muscle, colon, thymus, kidney, liver, small intestine and lung.

Genetic variants

268 - 268 R -> C (in dbSNP:rs35826078). VAR_041131 35826078
277 - 277 K -> E (in TGCT; somatic mutation). VAR_023827
322 - 322 R -> W (in dbSNP:rs56214442). VAR_041132 56214442
336 - 336 T -> I (in dbSNP:rs55972616). VAR_041133 55972616
467 - 467 N -> S (in dbSNP:rs56063773). VAR_041134 56063773
480 - 480 P -> L (in dbSNP:rs34505340). VAR_051671 34505340
520 - 520 P -> L (in dbSNP:rs17074311). VAR_051672 17074311
710 - 710 M -> T (in dbSNP:rs34936670). VAR_041135 34936670
853 - 853 S -> L (in dbSNP:rs56066852). VAR_041136 56066852
905 - 905 S -> T (in dbSNP:rs55791916). VAR_041137 55791916
942 - 942 S -> N (in dbSNP:rs1128204). VAR_051673 1128204
947 - 947 C -> Y (in dbSNP:rs56355550). VAR_041138 56355550

Database cross-references

UniProt: O94804
Ensembl: ENST00000176763
MIM: 273300
MIM: 603919
neXtProt: NX_O94804
Antibodypedia: O94804 (may not find the protein thus also not any antibody)
Local full text data: click here

Users' comments

Login to add a comment.

© Hegelab and Biomembrane 2013; Powered by TurboGears 2