STK10_HUMAN

Source: PM19886704
PM23856902
Marked as 'Membrane associated protein'
Confidence: low (only semi-automatic identification from reviews) Search PubMed for
(RBC AND this entry)

Gene names: STK10 , LOK
Protein names and data: STK10_HUMAN , Serine/threonine-protein kinase 10; 2.7.11.1 , Lymphocyte-oriented kinase Lenght: 968 a.a.
Mass: 112135 Da
fasta formatted sequence

Function: Serine/threonine-protein kinase involved in regulation of lymphocyte migration. Phosphorylates MSN, and possibly PLK1. Involved in regulation of lymphocyte migration by mediating phosphorylation of ERM proteins such as MSN. Acts as a negative regulator of MAP3K1/MEKK1. May also act as a cell cycle regulator by acting as a polo kinase kinase: mediates phosphorylation of PLK1 in vitro; however such data require additional evidences in vivo.
Catalytic activity: ATP + a protein = ADP + a phosphoprotein.
Disease:
Cellular location: Cell membrane; Peripheral membrane protein.
Tissue specificity: Highly expressed in rapidly proliferating tissues (spleen, placenta, and peripheral blood leukocytes). Also expressed in brain, heart, skeletal muscle, colon, thymus, kidney, liver, small intestine and lung.

Genetic variants

Database cross-references

UniProt: O94804
Ensembl: ENST00000176763
MIM: 273300
MIM: 603919
neXtProt: NX_O94804
Antibodypedia: O94804 (may not find the protein thus also not any antibody)
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