STK16_HUMAN

Source: PM23856902
Marked as 'Membrane associated protein'
Confidence: low (only semi-automatic identification from reviews) Search PubMed for
(RBC AND this entry)
Gene names: STK16 , MPSK1, PKL12, TSF1
Protein names and data: STK16_HUMAN , Serine/threonine-protein kinase 16; 2.7.11.1 , Myristoylated and palmitoylated serine/threonine-protein kinase; MPSK; Protein kinase PKL12; TGF-beta-stimulated factor 1; TSF-1; Tyrosine-protein kinase STK16; 2.7.10.2; hPSK Lenght: 305 a.a.
Mass: 34656 Da
fasta formatted sequence
Function: Membrane-associated protein kinase that phosphorylates on serine and threonine residues. In vitro substrates include DRG1, ENO1 and EIF4EBP1. Also autophosphorylates. May be involved in secretory vesicle trafficking or intracellular signaling. May have a role in regulating stromal-epithelial interactions that occur during ductal morphogenesis in the mammary gland. May be involved in TGF-beta signaling. Able to autophosphorylate on Tyr residue; it is however unclear whether it has tyrosine-protein kinase toward other proteins.
Catalytic activity: ATP + a protein = ADP + a phosphoprotein. ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
Cellular location: Cytoplasm, perinuclear region. Membrane; Lipid-anchor (By similarity). Note=Associates with Golgi and Golgi-derived vesicles (By similarity).
Tissue specificity: Ubiquitously expressed at very low levels.

Genetic variants

Database cross-references

UniProt: O75716
Ensembl: ENST00000396738
Ensembl: ENST00000409638
MIM: 604719
neXtProt: NX_O75716
Antibodypedia: O75716 (may not find the protein thus also not any antibody)
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