SWP70_HUMAN

Source: hRBCD ; ID: IPI00307200
PM19886704
PM23856902
Marked as 'Membrane associated protein'
Confidence: medium (present in either hRBCD or BSc_CH or PM22954596) Search PubMed for
(RBC AND this entry)
Gene names: SWAP70 , KIAA0640 , HSPC321
Protein names and data: SWP70_HUMAN , Switch-associated protein 70; SWAP-70 Lenght: 585 a.a.
Mass: 68998 Da
fasta formatted sequence
Function: Phosphatidylinositol 3,4,5-trisphosphate-dependent guanine nucleotide exchange factor (GEF) which, independently of RAS, transduces signals from tyrosine kinase receptors to RAC. It also mediates signaling of membrane ruffling. Regulates the actin cytoskeleton as an effector or adapter protein in response to agonist stimulated phosphatidylinositol (3,4)-bisphosphate production and cell protrusion (By similarity).
Cellular location: Cytoplasm. Cell membrane. Nucleus. Cell projection, lamellipodium. Note=In resting B-cells it is localized mainly in the cytoplasm and upon cell activation it is recruited to the plasma membrane and then translocates to the nucleus. In activated, class-switching B-cells it is associated with membrane IgG but not IgM. Localized to loose actin filament arrays located behind actively extending lamellipodia.
Tissue specificity: Expressed only in mature B-cells including those associated with mucosa-associated tissue and bronchus- associated tissue (PubMed:10681448). Widely expressed. Abundant in spleen, and fairly abundant in kidney, lung and liver. Also found in monocytes and macrophages (PubMed:12925760).

Genetic variants

Database cross-references

UniProt: Q9UH65
Ensembl: ENST00000318950
MIM: 604762
neXtProt: NX_Q9UH65
Antibodypedia: Q9UH65 (may not find the protein thus also not any antibody)
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