SYDC_HUMAN

Source: hRBCD ; ID: IPI00216951
PM19886704
PM23856902
Marked as 'Non-membrane protein'
Confidence: medium (present in either hRBCD or BSc_CH or PM22954596) Search PubMed for
(RBC AND this entry)

Gene names: DARS , PIG40
Protein names and data: SYDC_HUMAN , Aspartate--tRNA ligase, cytoplasmic; 6.1.1.12 , Aspartyl-tRNA synthetase; AspRS; Cell proliferation-inducing gene 40 protein Lenght: 501 a.a.
Mass: 57136 Da
fasta formatted sequence

Function: Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA.
Catalytic activity: ATP + L-aspartate + tRNA(Asp) = AMP + diphosphate + L-aspartyl-tRNA(Asp).
Disease:
Cellular location: Cytoplasm.
Tissue specificity: Expression in the developing and adult brain shows similar patterns. Highly expressed in the ventricular and subventricular zones, including hippocampal subfields, the midlateral temporaal cortex and the frontal polar cortex. The cerebellum, cereral cortex, hippocampus, and lateral ventricle show preferential neuronal expression. Expression in the peripheral neurons is evident in the colon.

Genetic variants

Database cross-references

UniProt: P14868
Ensembl: ENST00000264161
MIM: 603084
MIM: 615281
neXtProt: NX_P14868
Antibodypedia: P14868 (may not find the protein thus also not any antibody)
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