SYEP_HUMAN

Source: PM19886704
PM23856902
Marked as 'Non-membrane protein'
Confidence: low (only semi-automatic identification from reviews) Search PubMed for
(RBC AND this entry)
Gene names: EPRS , GLNS, PARS, QARS, QPRS , PIG32
Protein names and data: SYEP_HUMAN , Bifunctional glutamate/proline--tRNA ligase , Bifunctional aminoacyl-tRNA synthetase; Cell proliferation-inducing gene 32 protein; Glutamatyl-prolyl-tRNA synthetase; Glutamate--tRNA ligase; 6.1.1.17; Glutamyl-tRNA synthetase; GluRS; Proline--tRNA ligase; 6.1.1.15; Prolyl-tRNA synthetase Lenght: 1512 a.a.
Mass: 170591 Da
fasta formatted sequence
Function: Catalyzes the attachment of the cognate amino acid to the corresponding tRNA in a two-step reaction: the amino acid is first activated by ATP to form a covalent intermediate with AMP and is then transferred to the acceptor end of the cognate tRNA. Component of the GAIT (gamma interferon-activated inhibitor of translation) complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes. Upon interferon-gamma activation and subsequent phosphorylation dissociates from the multisynthetase complex and assembles into the GAIT complex which binds to stem loop- containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs (such as ceruplasmin) and suppresses their translation.
Catalytic activity: ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu). ATP + L-proline + tRNA(Pro) = AMP + diphosphate + L-prolyl-tRNA(Pro).
Cellular location: Cytoplasm (Probable).

Genetic variants

Database cross-references

UniProt: P07814
Ensembl: ENST00000366923
MIM: 138295
neXtProt: NX_P07814
Antibodypedia: P07814 (may not find the protein thus also not any antibody)
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