SYWC_HUMAN

Source: PM19886704
PM23856902
Marked as 'Non-membrane protein'
Confidence: low (only semi-automatic identification from reviews) Search PubMed for
(RBC AND this entry)
Gene names: WARS , IFI53, WRS
Protein names and data: SYWC_HUMAN , Tryptophan--tRNA ligase, cytoplasmic; 6.1.1.2 , Interferon-induced protein 53; IFP53; Tryptophanyl-tRNA synthetase; TrpRS; hWRS; T1-TrpRS; T2-TrpRS Lenght: 471 a.a.
Mass: 53165 Da
fasta formatted sequence
Function: Isoform 1, isoform 2 and T1-TrpRS have aminoacylation activity while T2-TrpRS lacks it. Isoform 2, T1-TrpRS and T2-TrpRS possess angiostatic activity whereas isoform 1 lacks it. T2-TrpRS inhibits fluid shear stress-activated responses of endothelial cells. Regulates ERK, Akt, and eNOS activation pathways that are associated with angiogenesis, cytoskeletal reorganization and shear stress-responsive gene expression.
Catalytic activity: ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + L-tryptophyl-tRNA(Trp).
Cellular location: Cytoplasm.

Genetic variants

Database cross-references

UniProt: P23381
Ensembl: ENST00000344102
Ensembl: ENST00000355338
Ensembl: ENST00000358655
Ensembl: ENST00000392882
Ensembl: ENST00000556645
Ensembl: ENST00000557135
MIM: 191050
neXtProt: NX_P23381
Antibodypedia: P23381 (may not find the protein thus also not any antibody)
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