TAB3_HUMAN

Source: PM19886704
PM23856902
Marked as 'Non-membrane protein'
Confidence: low (only semi-automatic identification from reviews) Search PubMed for
(RBC AND this entry)
Gene names: TAB3 , MAP3K7IP3
Protein names and data: TAB3_HUMAN , TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 , Mitogen-activated protein kinase kinase kinase 7-interacting protein 3; NF-kappa-B-activating protein 1; TAK1-binding protein 3; TAB-3; TGF-beta-activated kinase 1-binding protein 3 Lenght: 712 a.a.
Mass: 78683 Da
fasta formatted sequence
Function: Adapter linking MAP3K7/TAK1 and TRAF6 or TRAF2. Mediator of MAP3K7 activation, respectively in the IL1 and TNF signaling pathways. Plays a role in activation of NF-kappa-B and AP1 transcription factor. Isoform 2 may be an oncogenic factor.
Tissue specificity: Widely expressed. Constitutively overexpressed in certain tumor tissues. Isoform 1 is a major transcript while isoform 2 is a minor transcript.

Genetic variants

Database cross-references

UniProt: Q8N5C8
Ensembl: ENST00000288422
Ensembl: ENST00000378930
Ensembl: ENST00000378932
Ensembl: ENST00000378933
MIM: 300480
neXtProt: NX_Q8N5C8
Antibodypedia: Q8N5C8 (may not find the protein thus also not any antibody)
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