TAOK3_HUMAN

Source: PM19886704
PM23856902
Marked as 'Membrane associated protein'
Confidence: low (only semi-automatic identification from reviews) Search PubMed for
(RBC AND this entry)
Gene names: TAOK3 , DPK, JIK, KDS, MAP3K18
Protein names and data: TAOK3_HUMAN , Serine/threonine-protein kinase TAO3; 2.7.11.1 , Cutaneous T-cell lymphoma-associated antigen HD-CL-09; CTCL-associated antigen HD-CL-09; Dendritic cell-derived protein kinase; JNK/SAPK-inhibitory kinase; Jun kinase-inhibitory kinase; Kinase from chicken homolog A; hKFC-A; Thousand and one amino acid protein 3 Lenght: 898 a.a.
Mass: 105406 Da
fasta formatted sequence
Function: Serine/threonine-protein kinase that acts as a regulator of the p38/MAPK14 stress-activated MAPK cascade and of the MAPK8/JNK cascade. Acts as an activator of the p38/MAPK14 stress- activated MAPK cascade. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade, probably by mediating phosphorylation of upstream MAP2K3 and MAP2K6 kinases. Inhibits basal activity of MAPK8/JNK cascade and diminishes its activation in response epidermal growth factor (EGF).
Catalytic activity: ATP + a protein = ADP + a phosphoprotein.
Cellular location: Cytoplasm. Cell membrane; Peripheral membrane protein. Note=Also localized to the peripheral cell membrane.
Tissue specificity: Ubiquitously expressed at a low level, and highly expressed in peripheral blood leukocytes (PBLs), thymus, spleen, kidney, skeletal muscle, heart and liver.

Genetic variants

Database cross-references

UniProt: Q9H2K8
Ensembl: ENST00000392533
Ensembl: ENST00000419821
neXtProt: NX_Q9H2K8
Antibodypedia: Q9H2K8 (may not find the protein thus also not any antibody)
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