RBCC Red Blood Cell Collection

TCEA1_HUMAN

Source: PM19886704
PM23856902
PM22954596
Marked as 'Non-membrane protein'
Confidence: medium (present in either hRBCD or BSc_CH or PM22954596) Search PubMed for
(RBC AND this entry)
Gene names: TCEA1 , GTF2S, TFIIS
Protein names and data: TCEA1_HUMAN , Transcription elongation factor A protein 1 , Transcription elongation factor S-II protein 1; Transcription elongation factor TFIIS.o Lenght: 301 a.a.
Mass: 33970 Da
fasta formatted sequence
Function: Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by S-II allows the resumption of elongation from the new 3'-terminus.
Disease: ( OMIM: 601425 ) Note=A chromosomal aberration involving TCEA1 may be a cause of salivary gland pleiomorphic adenomas (PA) [181030]. Pleiomorphic adenomas are the most common benign epithelial tumors of the salivary gland. Translocation t(3;8)(p21;q12) with PLAG1.
Cellular location: Nucleus.

Database cross-references

UniProt: P23193
Ensembl: ENST00000396401
Ensembl: ENST00000521604
MIM: 601425
neXtProt: NX_P23193
Antibodypedia: P23193 (may not find the protein thus also not any antibody)
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