TCPR1_HUMAN

Source: PM23856902
PM22954596
Marked as 'Membrane associated protein'
Confidence: medium (present in either hRBCD or BSc_CH or PM22954596) Search PubMed for
(RBC AND this entry)
Gene names: TECPR1 , KIAA1358
Protein names and data: TCPR1_HUMAN , Tectonin beta-propeller repeat-containing protein 1 Lenght: 1165 a.a.
Mass: 129696 Da
fasta formatted sequence
Function: Tethering factor involved in autophagy. Involved in autophagosome maturation by promoting the autophagosome fusion with lysosomes: acts by associating with both the ATG5-ATG12 conjugate and phosphatidylinositol-3-phosphate (PtdIns(3)P) present at the surface of autophagosomes. Also involved in selective autophagy against bacterial pathogens, by being required for phagophore/preautophagosomal structure biogenesis and maturation.
Cellular location: Cytoplasmic vesicle, autophagosome membrane. Lysosome membrane. Note=Localizes to Lysosome membranes, and binds PtdIns(3)P at the surface of autophagosome. Localizes to autolysosomes, a vesicle formed by the fusion between autophagosomes and lysosomes.

Genetic variants

Database cross-references

UniProt: Q7Z6L1
Ensembl: ENST00000379795
Ensembl: ENST00000447648
Ensembl: ENST00000542604
MIM: 614781
neXtProt: NX_Q7Z6L1
Antibodypedia: Q7Z6L1 (may not find the protein thus also not any antibody)
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