TFR1_HUMAN

Source: PM23856902
Marked as 'Integral membrane protein'
Confidence: low (only semi-automatic identification from reviews) Search PubMed for
(RBC AND this entry)
Gene names: TFRC
Protein names and data: TFR1_HUMAN , Transferrin receptor protein 1; TR; TfR; TfR1; Trfr , T9; p90; CD71; Transferrin receptor protein 1, serum form; sTfR Lenght: 760 a.a.
Mass: 84871 Da
fasta formatted sequence
Function: Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system (By similarity). A second ligand, the heditary hemochromatosis protein HFE, competes for binding with transferrin for an overlapping C-terminal binding site.
Cellular location: Cell membrane; Single-pass type II membrane protein. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV. Transferrin receptor protein 1, serum form: Secreted.

Genetic variants

Database cross-references

UniProt: P02786
Ensembl: ENST00000360110
Ensembl: ENST00000392396
MIM: 190010
neXtProt: NX_P02786
Antibodypedia: P02786 (may not find the protein thus also not any antibody)
Local full text data: click here

Users' comments

Login to add a comment.