TGM3_HUMAN

Source: PM19886704
PM23856902
Marked as 'Non-membrane protein'
Confidence: low (only semi-automatic identification from reviews) Search PubMed for
(RBC AND this entry)
Gene names: TGM3
Protein names and data: TGM3_HUMAN , Protein-glutamine gamma-glutamyltransferase E; 2.3.2.13 , Transglutaminase E; TG(E); TGE; TGase E; Transglutaminase-3; TGase-3; Protein-glutamine gamma-glutamyltransferase E 50 kDa catalytic chain; Protein-glutamine gamma-glutamyltransferase E 27 kDa non-catalytic chain; Flags: Precursor Lenght: 693 a.a.
Mass: 76632 Da
fasta formatted sequence
Function: Catalyzes the calcium-dependent formation of isopeptide cross-links between glutamine and lysine residues in various proteins, as well as the conjugation of polyamines to proteins. Involved in the formation of the cornified envelope (CE), a specialized component consisting of covalent cross-links of proteins beneath the plasma membrane of terminally differentiated keratinocytes. Catalyzes small proline-rich proteins (SPRR1 and SPRR2) and LOR cross-linking to form small interchain oligomers, which are further cross-linked by TGM1 onto the growing CE scaffold (By similarity). In hair follicles, involved in cross- linking structural proteins to hardening the inner root sheath.
Catalytic activity: Protein glutamine + alkylamine = protein N(5)- alkylglutamine + NH(3).

Genetic variants

Database cross-references

UniProt: Q08188
Ensembl: ENST00000381458
MIM: 600238
neXtProt: NX_Q08188
Antibodypedia: Q08188 (may not find the protein thus also not any antibody)
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