THIO_HUMAN

Source: hRBCD ; ID: IPI00216298
PM19886704
PM23856902
PM22954596
Marked as 'Non-membrane protein'
Confidence: high (present in two of the MS resources) Search PubMed for
(RBC AND this entry)
Gene names: TXN , TRDX, TRX, TRX1
Protein names and data: THIO_HUMAN , Thioredoxin; Trx , ATL-derived factor; ADF; Surface-associated sulphydryl protein; SASP Lenght: 105 a.a.
Mass: 11737 Da
fasta formatted sequence
Function: Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions. Plays a role in the reversible S-nitrosylation of cysteine residues in target proteins, and thereby contributes to the response to intracellular nitric oxide. Nitrosylates the active site Cys of CASP3 in response to nitric oxide (NO), and thereby inhibits caspase-3 activity. Induces the FOS/JUN AP-1 DNA-binding activity in ionizing radiation (IR) cells through its oxidation/reduction status and stimulates AP-1 transcriptional activity. ADF augments the expression of the interleukin-2 receptor TAC (IL2R/P55).
Cellular location: Nucleus. Cytoplasm. Secreted. Note=Secreted by a leaderless secretory pathway. Predominantly in the cytoplasm in non irradiated cells. Radiation induces translocation of TRX from the cytoplasm to the nucleus.

Database cross-references

UniProt: P10599
Ensembl: ENST00000374515
Ensembl: ENST00000374517
MIM: 187700
neXtProt: NX_P10599
Antibodypedia: P10599 (may not find the protein thus also not any antibody)
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