THOP1_HUMAN

Source: PM19886704
PM23856902
Marked as 'Non-membrane protein'
Confidence: low (only semi-automatic identification from reviews) Search PubMed for
(RBC AND this entry)
Gene names: THOP1
Protein names and data: THOP1_HUMAN , Thimet oligopeptidase; 3.4.24.15 , Endopeptidase 24.15; MP78 Lenght: 689 a.a.
Mass: 78840 Da
fasta formatted sequence
Function: Involved in the metabolism of neuropeptides under 20 amino acid residues long. Involved in cytoplasmic peptide degradation. Able to degrade the beta-amyloid precursor protein and generate amyloidogenic fragments.
Catalytic activity: Preferential cleavage of bonds with hydrophobic residues at P1, P2 and P3' and a small residue at P1' in substrates of 5 to 15 residues.
Cellular location: Cytoplasm.

Database cross-references

UniProt: P52888
Ensembl: ENST00000307741
MIM: 601117
neXtProt: NX_P52888
Antibodypedia: P52888 (may not find the protein thus also not any antibody)
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