THTM_HUMAN

Source: hRBCD ; ID: IPI00165360
PM19886704
PM23856902
Marked as 'Non-membrane protein'
Confidence: medium (present in either hRBCD or BSc_CH or PM22954596) Search PubMed for
(RBC AND this entry)
Gene names: MPST , TST2
Protein names and data: THTM_HUMAN , 3-mercaptopyruvate sulfurtransferase; MST; 2.8.1.2 Lenght: 297 a.a.
Mass: 33178 Da
fasta formatted sequence
Function: Transfer of a sulfur ion to cyanide or to other thiol compounds. Also has weak rhodanese activity. Detoxifies cyanide and is required for thiosulfate biosynthesis. Acts as an antioxidant. In combination with cysteine aminotransferase (CAT), contributes to the catabolism of cysteine and is an important producer of hydrogen sulfide in the brain, retina and vascular endothelial cells. Hydrogen sulfide H(2)S is an important synaptic modulator, signaling molecule, smooth muscle contractor and neuroprotectant. Its production by the 3MST/CAT pathway is regulated by calcium ions (By similarity).
Catalytic activity: 3-mercaptopyruvate + cyanide = pyruvate + thiocyanate.
Disease:
Cellular location: Cytoplasm (By similarity). Mitochondrion (By similarity). Cell junction, synapse, synaptosome (By similarity).

Database cross-references

UniProt: P25325
Ensembl: ENST00000341116
Ensembl: ENST00000397225
Ensembl: ENST00000401419
Ensembl: ENST00000404802
Ensembl: ENST00000429360
MIM: 249650
MIM: 602496
neXtProt: NX_P25325
Antibodypedia: P25325 (may not find the protein thus also not any antibody)
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