TM55B_HUMAN

Source: hRBCD ; ID: IPI00030530
PM19886704
PM23856902
BSc_CH
Marked as 'Integral membrane protein'
Confidence: high (present in two of the MS resources) Search PubMed for
(RBC AND this entry)
Gene names: TMEM55B , C14orf9
Protein names and data: TM55B_HUMAN , Type 1 phosphatidylinositol 4,5-bisphosphate 4-phosphatase; Type 1 PtdIns-4,5-P2 4-Ptase; 3.1.3.78 , PtdIns-4,5-P2 4-Ptase I; Transmembrane protein 55B Lenght: 277 a.a.
Mass: 29470 Da
fasta formatted sequence
Function: Catalyzes the hydrolysis of the 4-position phosphate of phosphatidylinositol 4,5-bisphosphate. Does not hydrolyze phosphatidylinositol 3,4,5-trisphosphate, phosphatidylinositol 3,4-bisphosphate, inositol 3,5-bisphosphate, inositol 3,4- bisphosphate, phosphatidylinositol 5-monophosphate, phosphatidylinositol 4-monophosphate and phosphatidylinositol 3- monophosphate.
Catalytic activity: 1-phosphatidyl-myo-inositol 4,5-bisphosphate + H(2)O = 1-phosphatidyl-1D-myo-inositol 5-phosphate + phosphate. 1-phosphatidyl-1D-myo-inositol 4,5- bisphosphate + H(2)O = 1-phosphatidyl-1D-myo-inositol 5-phosphate + phosphate.
Cellular location: Late endosome membrane; Multi-pass membrane protein. Lysosome membrane; Multi-pass membrane protein.
Tissue specificity: Ubiquitous.

Database cross-references

UniProt: Q86T03
Ensembl: ENST00000250489
Ensembl: ENST00000398020
MIM: 609865
neXtProt: NX_Q86T03
Antibodypedia: Q86T03 (may not find the protein thus also not any antibody)
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