TMED9_HUMAN

Source: hRBCD ; ID: IPI00023542
PM19886704
PM23856902
BSc_CH
Marked as 'Integral membrane protein'
Confidence: high (present in two of the MS resources) Search PubMed for
(RBC AND this entry)
Gene names: TMED9 , GP25L2
Protein names and data: TMED9_HUMAN , Transmembrane emp24 domain-containing protein 9 , GMP25; Glycoprotein 25L2; p24 family protein alpha-2; p24alpha2; p25; Flags: Precursor Lenght: 235 a.a.
Mass: 27277 Da
fasta formatted sequence
Function: Appears to be involved in vesicular protein trafficking, mainly in the early secretory pathway. In COPI vesicle-mediated retrograde transport involved in the coatomer recruitment to membranes of the early secretory pathway. Increases coatomer- dependent activity of ARFGAP2. Thought to play a crucial role in the specific retention of p24 complexes in cis-Golgi membranes; specifically contributes to the coupled localization of TMED2 and TMED10 in the cis-Golgi network. May be involved in organization of intracellular membranes, such as of the ER-Golgi intermediate compartment and the Golgi apparatus. Involved in ER localization of PTPN2 isoform PTPB.
Cellular location: Endoplasmic reticulum membrane; Single-pass type I membrane protein. Golgi apparatus, cis-Golgi network membrane; Single-pass type I membrane protein. Endoplasmic reticulum-Golgi intermediate compartment membrane; Single-pass type I membrane protein. Golgi apparatus, trans-Golgi network membrane; Single-pass type I membrane protein (By similarity). Note=Cycles between compartments of the early secretatory pathway.

Genetic variants

Database cross-references

UniProt: Q9BVK6
Ensembl: ENST00000332598
neXtProt: NX_Q9BVK6
Antibodypedia: Q9BVK6 (may not find the protein thus also not any antibody)
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