TNF14_HUMAN

Source: PM19886704
PM23856902
Marked as 'Integral membrane protein'
Confidence: low (only semi-automatic identification from reviews) Search PubMed for
(RBC AND this entry)
Gene names: TNFSF14 , HVEML, LIGHT , UNQ391/PRO726
Protein names and data: TNF14_HUMAN , Tumor necrosis factor ligand superfamily member 14 , Herpes virus entry mediator ligand; HVEM-L; Herpesvirus entry mediator ligand; CD258; Tumor necrosis factor ligand superfamily member 14, membrane form; Tumor necrosis factor ligand superfamily member 14, soluble form Lenght: 240 a.a.
Mass: 26350 Da
fasta formatted sequence
Function: Cytokine that binds to TNFRSF3/LTBR. Binding to the decoy receptor TNFRSF6B modulates its effects. Activates NFKB, stimulates the proliferation of T-cells, and inhibits growth of the adenocarcinoma HT-29. Acts as a receptor for Herpes simplex virus.
Cellular location: Tumor necrosis factor ligand superfamily member 14, membrane form: Cell membrane; Single-pass type II membrane protein. Tumor necrosis factor ligand superfamily member 14, soluble form: Secreted. Isoform 2: Cytoplasm.
Tissue specificity: Predominantly expressed in the spleen but also found in the brain. Weakly expressed in peripheral lymphoid tissues and in heart, placenta, liver, lung, appendix, and kidney, and no expression seen in fetal tissues, endocrine glands, or nonhematopoietic tumor lines.

Genetic variants

Database cross-references

UniProt: O43557
Ensembl: ENST00000245912
Ensembl: ENST00000326176
Ensembl: ENST00000599359
MIM: 604520
neXtProt: NX_O43557
Antibodypedia: O43557 (may not find the protein thus also not any antibody)
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