TNPO2_HUMAN

Source: PM19886704
PM23856902
Marked as 'Non-membrane protein'
Confidence: low (only semi-automatic identification from reviews) Search PubMed for
(RBC AND this entry)
Gene names: TNPO2
Protein names and data: TNPO2_HUMAN , Transportin-2 , Karyopherin beta-2b Lenght: 897 a.a.
Mass: 101388 Da
fasta formatted sequence
Function: Probably functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity).
Cellular location: Cytoplasm (By similarity). Nucleus (By similarity).

Genetic variants

Database cross-references

UniProt: O14787
Ensembl: ENST00000356861
Ensembl: ENST00000425528
Ensembl: ENST00000441499
Ensembl: ENST00000450764
Ensembl: ENST00000588216
Ensembl: ENST00000592287
MIM: 603002
neXtProt: NX_O14787
Antibodypedia: O14787 (may not find the protein thus also not any antibody)
Local full text data: click here

Users' comments

Login to add a comment.