Source: BD_CD
Marked as 'Integral membrane protein'
Confidence: high (a blood group or CD marker) Search PubMed for
(RBC AND this entry)

Gene names: TNFRSF1A , TNFAR, TNFR1
Protein names and data: TNR1A_HUMAN , Tumor necrosis factor receptor superfamily member 1A , Tumor necrosis factor receptor 1; TNF-R1; Tumor necrosis factor receptor type I; TNF-RI; TNFR-I; p55; p60; CD120a; Tumor necrosis factor receptor superfamily member 1A, membrane form; Tumor necrosis factor-binding protein 1; TBPI; Flags: Precursor Lenght: 455 a.a.
Mass: 50495 Da
fasta formatted sequence

Function: Receptor for TNFSF2/TNF-alpha and homotrimeric TNFSF1/lymphotoxin-alpha. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate- specific cysteine proteases) mediating apoptosis. Contributes to the induction of non-cytocidal TNF effects including anti-viral state and activation of the acid sphingomyelinase.
Cellular location: Cell membrane; Single-pass type I membrane protein. Golgi apparatus membrane; Single-pass type I membrane protein. Secreted. Note=A secreted form is produced through proteolytic processing. Isoform 4: Secreted. Note=Lacks a Golgi- retention motif, is not membrane bound and therefore is secreted.

Genetic variants

Database cross-references

UniProt: P19438
Ensembl: ENST00000162749
Ensembl: ENST00000366159
MIM: 142680
MIM: 191190
MIM: 614810
neXtProt: NX_P19438
Antibodypedia: P19438 (may not find the protein thus also not any antibody)
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