Source: PM23856902
Marked as 'Integral membrane protein'
Confidence: medium (present in either hRBCD or BSc_CH or PM22954596) Search PubMed for
(RBC AND this entry)

Gene names: FAS , APT1, FAS1, TNFRSF6
Protein names and data: TNR6_HUMAN , Tumor necrosis factor receptor superfamily member 6 , Apo-1 antigen; Apoptosis-mediating surface antigen FAS; FASLG receptor; CD95; Flags: Precursor Lenght: 335 a.a.
Mass: 37732 Da
fasta formatted sequence

Function: Receptor for TNFSF6/FASLG. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death- inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. FAS- mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. The secreted isoforms 2 to 6 block apoptosis (in vitro).
Cellular location: Isoform 1: Cell membrane; Single-pass type I membrane protein. Isoform 2: Secreted. Isoform 3: Secreted. Isoform 4: Secreted. Isoform 5: Secreted. Isoform 6: Secreted.
Tissue specificity: Isoform 1 and isoform 6 are expressed at equal levels in resting peripheral blood mononuclear cells. After activation there is an increase in isoform 1 and decrease in the levels of isoform 6.

Genetic variants

Database cross-references

UniProt: P25445
Ensembl: ENST00000355279
Ensembl: ENST00000355740
Ensembl: ENST00000357339
Ensembl: ENST00000479522
Ensembl: ENST00000484444
Ensembl: ENST00000488877
Ensembl: ENST00000492756
Ensembl: ENST00000494410
MIM: 134637
MIM: 601859
neXtProt: NX_P25445
Antibodypedia: P25445 (may not find the protein thus also not any antibody)
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