TOPK_HUMAN

Source: PM19886704
PM23856902
Marked as 'Non-membrane protein'
Confidence: low (only semi-automatic identification from reviews) Search PubMed for
(RBC AND this entry)
Gene names: PBK , TOPK
Protein names and data: TOPK_HUMAN , Lymphokine-activated killer T-cell-originated protein kinase; 2.7.12.2 , Cancer/testis antigen 84; CT84; MAPKK-like protein kinase; Nori-3; PDZ-binding kinase; Spermatogenesis-related protein kinase; SPK; T-LAK cell-originated protein kinase Lenght: 322 a.a.
Mass: 36085 Da
fasta formatted sequence
Function: Phosphorylates MAP kinase p38. Seems to be active only in mitosis. May also play a role in the activation of lymphoid cells. When phosphorylated, forms a complex with TP53, leading to TP53 destabilization and attenuation of G2/M checkpoint during doxorubicin-induced DNA damage.
Catalytic activity: ATP + a protein = ADP + a phosphoprotein.
Tissue specificity: Expressed in the testis and placenta. In the testis, restrictedly expressed in outer cell layer of seminiferous tubules.

Genetic variants

Database cross-references

UniProt: Q96KB5
Ensembl: ENST00000301905
MIM: 611210
neXtProt: NX_Q96KB5
Antibodypedia: Q96KB5 (may not find the protein thus also not any antibody)
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