TPM4_HUMAN

Source: hRBCD ; ID: IPI00010779
PM19886704
PM23856902
Marked as 'Non-membrane protein'
Confidence: medium (present in either hRBCD or BSc_CH or PM22954596) Search PubMed for
(RBC AND this entry)
Gene names: TPM4
Protein names and data: TPM4_HUMAN , Tropomyosin alpha-4 chain , TM30p1; Tropomyosin-4 Lenght: 248 a.a.
Mass: 28522 Da
fasta formatted sequence
Function: Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments. Binds calcium.
Cellular location: Cytoplasm, cytoskeleton.
Tissue specificity: Detected in cardiac tissue and platelets, the form found in cardiac tissue is a higher molecular weight than the form found in platelets. Expressed at higher levels in the platelets of hypertensive patients with cardiac hypertrophy than in the platelets of hypertensive patients without cardiac hypertrophy (at protein level).

Genetic variants

Database cross-references

UniProt: P67936
Ensembl: ENST00000300933
Ensembl: ENST00000344824
Ensembl: ENST00000538887
MIM: 600317
neXtProt: NX_P67936
Antibodypedia: P67936 (may not find the protein thus also not any antibody)
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