TRADD_HUMAN

Source: PM19886704
PM23856902
Marked as 'Non-membrane protein'
Confidence: low (only semi-automatic identification from reviews) Search PubMed for
(RBC AND this entry)
Gene names: TRADD
Protein names and data: TRADD_HUMAN , Tumor necrosis factor receptor type 1-associated DEATH domain protein; TNFR1-associated DEATH domain protein , TNFRSF1A-associated via death domain Lenght: 312 a.a.
Mass: 34247 Da
fasta formatted sequence
Function: The nuclear form acts as a tumor suppressor by preventing ubiquitination and degradation of isoform p19ARF/ARF of CDKN2A by TRIP12: acts by interacting with TRIP12, leading to disrupt interaction between TRIP12 and isoform p19ARF/ARF of CDKN2A (By similarity). Adapter molecule for TNFRSF1A/TNFR1 that specifically associates with the cytoplasmic domain of activated TNFRSF1A/TNFR1 mediating its interaction with FADD. Overexpression of TRADD leads to two major TNF-induced responses, apoptosis and activation of NF-kappa-B.
Cellular location: Nucleus (By similarity). Cytoplasm (By similarity). Cytoplasm, cytoskeleton. Note=Shuttles between the cytoplasm and the nucleus (By similarity).
Tissue specificity: Found in all examined tissues.

Database cross-references

UniProt: Q15628
Ensembl: ENST00000345057
MIM: 603500
neXtProt: NX_Q15628
Antibodypedia: Q15628 (may not find the protein thus also not any antibody)
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