TRAP1_HUMAN

Source: PM19886704
PM23856902
Marked as 'Membrane associated protein'
Confidence: low (only semi-automatic identification from reviews) Search PubMed for
(RBC AND this entry)
Gene names: TRAP1 , HSP75
Protein names and data: TRAP1_HUMAN , Heat shock protein 75 kDa, mitochondrial; HSP 75 , TNFR-associated protein 1; Tumor necrosis factor type 1 receptor-associated protein; TRAP-1; Flags: Precursor Lenght: 704 a.a.
Mass: 80110 Da
fasta formatted sequence
Function: Chaperone that expresses an ATPase activity. Involved in maintaining mitochondrial function and polarization, most likely through stabilization of mitochondrial complex I. Is a negative regulator of mitochondrial respiration able to modulate the balance between oxidative phosphorylation and aerobic glycolysis. The impact of TRAP1 on mitochondrial respiration is probably mediated by modulation of mitochondrial SRC and inhibition of SDHA.
Cellular location: Mitochondrion. Mitochondrion inner membrane. Mitochondrion matrix.
Tissue specificity: Found in skeletal muscle, liver, heart, brain, kidney, pancreas, lung, placenta and bladder. Expression is higly reduced in bladder cancer and renal cell carcinoma specimens compared to healthy tissues, but it is increased in other type of tumors.

Genetic variants

Database cross-references

UniProt: Q12931
Ensembl: ENST00000246957
MIM: 606219
neXtProt: NX_Q12931
Antibodypedia: Q12931 (may not find the protein thus also not any antibody)
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