TRI23_HUMAN

Source: PM19886704
PM23856902
Marked as 'Membrane associated protein'
Confidence: low (only semi-automatic identification from reviews) Search PubMed for
(RBC AND this entry)
Gene names: TRIM23 , ARD1, ARFD1, RNF46
Protein names and data: TRI23_HUMAN , E3 ubiquitin-protein ligase TRIM23; 6.3.2.- , ADP-ribosylation factor domain-containing protein 1; GTP-binding protein ARD-1; RING finger protein 46; Tripartite motif-containing protein 23 Lenght: 574 a.a.
Mass: 64067 Da
fasta formatted sequence
Function: Acts as an E3 ubiquitin-protein ligase. In the presence of the human cytomegalovirus (HCMV) protein UL144, participates in 'Lys-63'-linked auto-ubiquitination of TRAF6 resulting in the virally controlled activation of NF-kappa-B at early time of infection. The C-terminus can act as an allosteric activator of the cholera toxin catalytic subunit.
Pathway: Protein modification; protein ubiquitination.
Cellular location: Endomembrane system. Golgi apparatus membrane. Lysosome membrane. Note=Membrane-associated with the Golgi complex and lysosomal structures.

Genetic variants

Database cross-references

UniProt: P36406
Ensembl: ENST00000231524
Ensembl: ENST00000274327
Ensembl: ENST00000381018
MIM: 601747
neXtProt: NX_P36406
Antibodypedia: P36406 (may not find the protein thus also not any antibody)
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