TRXR1_HUMAN
Source: PM19886704PM23856902
Marked as 'Non-membrane protein'
Confidence: low (only semi-automatic identification from reviews) Search PubMed for
(RBC AND this entry)
Gene names: TXNRD1 , GRIM12, KDRF
Protein names and data: TRXR1_HUMAN , Thioredoxin reductase 1, cytoplasmic; TR; 1.8.1.9 , Gene associated with retinoic and interferon-induced mortality 12 protein; GRIM-12; Gene associated with retinoic and IFN-induced mortality 12 protein; KM-102-derived reductase-like factor; Thioredoxin reductase TR1 Lenght: 649 a.a.
Mass: 70906 Da
fasta formatted sequence
Function: Isoform 1 may possess glutaredoxin activity as well as thioredoxin reductase activity and induces actin and tubulin polymerization, leading to formation of cell membrane protrusions. Isoform 4 enhances the transcriptional activity of estrogen receptors alpha and beta while isoform 5 enhances the transcriptional activity of the beta receptor only. Isoform 5 also mediates cell death induced by a combination of interferon-beta and retinoic acid.
Catalytic activity: Thioredoxin + NADP(+) = thioredoxin disulfide + NADPH.
Cellular location: Cytoplasm (By similarity). Isoform 4: Cytoplasm. Nucleus. Isoform 5: Cytoplasm.
Tissue specificity: Isoform 1 is expressed predominantly in Leydig cells (at protein level). Also expressed in ovary, spleen, heart, liver, kidney and pancreas and in a number of cancer cell lines. Isoform 4 is widely expressed with highest levels in kidney, testis, uterus, ovary, prostate, placenta and fetal liver.
Genetic variants
Database cross-references
UniProt: Q16881Ensembl: ENST00000388854
Ensembl: ENST00000503506
Ensembl: ENST00000524698
Ensembl: ENST00000525566
Ensembl: ENST00000526390
Ensembl: ENST00000526580
Ensembl: ENST00000526691
MIM: 601112
neXtProt: NX_Q16881
Antibodypedia: Q16881 (may not find the protein thus also not any antibody)
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