TSN_HUMAN

Source: PM19886704
PM23856902
PM22954596
Marked as 'Non-membrane protein'
Confidence: medium (present in either hRBCD or BSc_CH or PM22954596) Search PubMed for
(RBC AND this entry)
Gene names: TSN
Protein names and data: TSN_HUMAN , Translin; 3.1.-.- , Component 3 of promoter of RISC; C3PO Lenght: 228 a.a.
Mass: 26183 Da
fasta formatted sequence
Function: DNA-binding protein that specifically recognizes consensus sequences at the breakpoint junctions in chromosomal translocations, mostly involving immunoglobulin (Ig)/T-cell receptor gene segments. Seems to recognize single-stranded DNA ends generated by staggered breaks occurring at recombination hot spots. Exhibits both single-stranded and double-stranded endoribonuclease activity. May act as an activator of RNA-induced silencing complex (RISC) by facilitating endonucleolytic cleavage of the siRNA passenger strand.
Cellular location: Cytoplasm. Nucleus.

Database cross-references

UniProt: Q15631
Ensembl: ENST00000389682
Ensembl: ENST00000536142
MIM: 600575
neXtProt: NX_Q15631
Antibodypedia: Q15631 (may not find the protein thus also not any antibody)
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