UB2L3_HUMAN

Source: PM19886704
PM23856902
PM22954596
Marked as 'Non-membrane protein'
Confidence: medium (present in either hRBCD or BSc_CH or PM22954596) Search PubMed for
(RBC AND this entry)
Gene names: UBE2L3 , UBCE7, UBCH7
Protein names and data: UB2L3_HUMAN , Ubiquitin-conjugating enzyme E2 L3; 6.3.2.19 , L-UBC; UbcH7; Ubiquitin carrier protein L3; Ubiquitin-conjugating enzyme E2-F1; Ubiquitin-protein ligase L3 Lenght: 154 a.a.
Mass: 17862 Da
fasta formatted sequence
Function: Ubiquitin-conjugating enzyme E2 that specifically acts with HECT-type and RBR family E3 ubiquitin-protein ligases. Does not function with most RING-containing E3 ubiquitin-protein ligases because it lacks intrinsic E3-independent reactivity with lysine: in contrast, it has activity with the RBR family E3 enzymes, such as PARK2 and ARIH1, that function like function like RING-HECT hybrids. Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-11'-linked polyubiquitination. Involved in the selective degradation of short-lived and abnormal proteins. Down- regulated during the S-phase it is involved in progression through the cell cycle. Regulates nuclear hormone receptors transcriptional activity. May play a role in myelopoiesis.
Catalytic activity: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine.
Pathway: Protein modification; protein ubiquitination.
Cellular location: Nucleus. Cytoplasm.
Tissue specificity: Ubiquitous, with highest expression in testis.

Database cross-references

UniProt: P68036
Ensembl: ENST00000342192
Ensembl: ENST00000458578
Ensembl: ENST00000545681
MIM: 603721
neXtProt: NX_P68036
Antibodypedia: P68036 (may not find the protein thus also not any antibody)
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