UB2V1_HUMAN

Source: hRBCD ; ID: IPI00019599
PM23856902
PM22954596
Marked as 'Non-membrane protein'
Confidence: high (present in two of the MS resources) Search PubMed for
(RBC AND this entry)
Gene names: UBE2V1 , CROC1, UBE2V, UEV1 , P/OKcl.19
Protein names and data: UB2V1_HUMAN , Ubiquitin-conjugating enzyme E2 variant 1; UEV-1 , CROC-1; TRAF6-regulated IKK activator 1 beta Uev1A Lenght: 147 a.a.
Mass: 16495 Da
fasta formatted sequence
Function: Has no ubiquitin ligase activity on its own. The UBE2V1- UBE2N heterodimer catalyzes the synthesis of non-canonical poly- ubiquitin chains that are linked through Lys-63. This type of poly-ubiquitination activates IKK and does not seem to involve protein degradation by the proteasome. Plays a role in the activation of NF-kappa-B mediated by IL1B, TNF, TRAF6 and TRAF2. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage. Promotes TRIM5 capsid-specific restriction activity and the UBE2V1-UBE2N heterodimer acts in concert with TRIM5 to generate 'Lys-63'-linked polyubiquitin chains which activate the MAP3K7/TAK1 complex which in turn results in the induction and expression of NF-kappa-B and MAPK-responsive inflammatory genes.
Cellular location: Nucleus. Note=Excluded from the nucleolus.
Tissue specificity: Highly expressed in thyroid, pancreas, spinal cord, lymph node, trachea, adrenal gland, bone marrow and pancreas. Detected at low levels in heart, breast, placenta, brain, liver, kidney, stomach and lung.

Database cross-references

UniProt: Q13404
Ensembl: ENST00000340309
Ensembl: ENST00000371657
Ensembl: ENST00000371674
Ensembl: ENST00000371677
Ensembl: ENST00000415862
Ensembl: ENST00000420027
MIM: 602995
neXtProt: NX_Q13404
Antibodypedia: Q13404 (may not find the protein thus also not any antibody)
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