UB2V2_HUMAN

Source: PM23856902
Marked as 'Non-membrane protein'
Confidence: low (only semi-automatic identification from reviews) Search PubMed for
(RBC AND this entry)
Gene names: UBE2V2 , MMS2, UEV2
Protein names and data: UB2V2_HUMAN , Ubiquitin-conjugating enzyme E2 variant 2 , DDVit 1; Enterocyte differentiation-associated factor 1; EDAF-1; Enterocyte differentiation-promoting factor 1; EDPF-1; MMS2 homolog; Vitamin D3-inducible protein Lenght: 145 a.a.
Mass: 16363 Da
fasta formatted sequence
Function: Has no ubiquitin ligase activity on its own. The UBE2V2/UBE2N heterodimer catalyzes the synthesis of non-canonical poly-ubiquitin chains that are linked through 'Lys-63'. This type of poly-ubiquitination does not lead to protein degradation by the proteasome. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage.
Tissue specificity: Detected in placenta, colon, liver and skin. Detected at very low levels in most tissues.

Genetic variants

Database cross-references

UniProt: Q15819
Ensembl: ENST00000523111
MIM: 603001
neXtProt: NX_Q15819
Antibodypedia: Q15819 (may not find the protein thus also not any antibody)
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