UBA3_HUMAN

Source: PM19886704
PM23856902
Marked as 'Non-membrane protein'
Confidence: low (only semi-automatic identification from reviews) Search PubMed for
(RBC AND this entry)
Gene names: UBA3 , UBE1C
Protein names and data: UBA3_HUMAN , NEDD8-activating enzyme E1 catalytic subunit; 6.3.2.- , NEDD8-activating enzyme E1C; Ubiquitin-activating enzyme E1C; Ubiquitin-like modifier-activating enzyme 3; Ubiquitin-activating enzyme 3 Lenght: 463 a.a.
Mass: 51852 Da
fasta formatted sequence
Function: Catalytic subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Down-regulates steroid receptor activity. Necessary for cell cycle progression.
Pathway: Protein modification; protein neddylation.
Tissue specificity: Ubiquitously expressed.

Genetic variants

Database cross-references

UniProt: Q8TBC4
Ensembl: ENST00000349511
Ensembl: ENST00000361055
MIM: 603172
neXtProt: NX_Q8TBC4
Antibodypedia: Q8TBC4 (may not find the protein thus also not any antibody)
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