UBA6_HUMAN

Source: PM19886704
PM23856902
Marked as 'Non-membrane protein'
Confidence: low (only semi-automatic identification from reviews) Search PubMed for
(RBC AND this entry)
Gene names: UBA6 , MOP4, UBE1L2
Protein names and data: UBA6_HUMAN , Ubiquitin-like modifier-activating enzyme 6; Ubiquitin-activating enzyme 6 , Monocyte protein 4; MOP-4; Ubiquitin-activating enzyme E1-like protein 2; E1-L2 Lenght: 1052 a.a.
Mass: 117970 Da
fasta formatted sequence
Function: Activates ubiquitin by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding an ubiquitin- E1 thioester and free AMP. Specific for ubiquitin, does not activate ubiquitin-like peptides. Differs from UBE1 in its specificity for substrate E2 charging. Does not charge cell cycle E2s, such as CDC34. Essential for embryonic development. Required for UBD/FAT10 conjugation. Isoform 2 may play a key role in ubiquitin system and may influence spermatogenesis and male fertility.
Pathway: Protein modification; protein ubiquitination.
Tissue specificity: Widely expressed. Isoform 2 is predominantly expressed in testis with higher expression in adult testis than in fetal testis.

Genetic variants

Database cross-references

UniProt: A0AVT1
Ensembl: ENST00000322244
Ensembl: ENST00000420827
MIM: 611361
neXtProt: NX_A0AVT1
Antibodypedia: A0AVT1 (may not find the protein thus also not any antibody)
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