UBC12_HUMAN

Source: PM19886704
PM23856902
Marked as 'Non-membrane protein'
Confidence: low (only semi-automatic identification from reviews) Search PubMed for
(RBC AND this entry)
Gene names: UBE2M , UBC12
Protein names and data: UBC12_HUMAN , NEDD8-conjugating enzyme Ubc12; 6.3.2.- , NEDD8 carrier protein; NEDD8 protein ligase; Ubiquitin-conjugating enzyme E2 M Lenght: 183 a.a.
Mass: 20900 Da
fasta formatted sequence
Function: Accepts the ubiquitin-like protein NEDD8 from the UBA3- NAE1 E1 complex and catalyzes its covalent attachment to other proteins. The specific interaction with the E3 ubiquitin ligase RBX1, but not RBX2, suggests that the RBX1-UBE2M complex neddylates specific target proteins, such as CUL1, CUL2, CUL3 and CUL4. Involved in cell proliferation.
Catalytic activity: ATP + NEDD8 + protein lysine = AMP + diphosphate + protein N-NEDD8yllysine.
Pathway: Protein modification; protein neddylation.

Database cross-references

UniProt: P61081
Ensembl: ENST00000253023
MIM: 603173
neXtProt: NX_P61081
Antibodypedia: P61081 (may not find the protein thus also not any antibody)
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