UBC9_HUMAN

Source: hRBCD ; ID: IPI00032957
PM19886704
PM23856902
Marked as 'Non-membrane protein'
Confidence: medium (present in either hRBCD or BSc_CH or PM22954596) Search PubMed for
(RBC AND this entry)
Gene names: UBE2I , UBC9, UBCE9
Protein names and data: UBC9_HUMAN , SUMO-conjugating enzyme UBC9; 6.3.2.- , SUMO-protein ligase; Ubiquitin carrier protein 9; Ubiquitin carrier protein I; Ubiquitin-conjugating enzyme E2 I; Ubiquitin-protein ligase I; p18 Lenght: 158 a.a.
Mass: 18007 Da
fasta formatted sequence
Function: Accepts the ubiquitin-like proteins SUMO1, SUMO2, SUMO3 and SUMO4 from the UBLE1A-UBLE1B E1 complex and catalyzes their covalent attachment to other proteins with the help of an E3 ligase such as RANBP2 or CBX4. Can catalyze the formation of poly- SUMO chains. Necessary for sumoylation of FOXL2 and KAT5. Essential for nuclear architecture and chromosome segregation. Sumoylates p53/TP53 at 'Lys-386'.
Catalytic activity: ATP + SUMO + protein lysine = AMP + diphosphate + protein N-SUMOyllysine.
Pathway: Protein modification; protein sumoylation.
Cellular location: Nucleus. Cytoplasm. Note=Mainly nuclear. In spermatocytes, localizes in synaptonemal complexes. Recruited by BCL11A into the nuclear body (By similarity).
Tissue specificity: Expressed in heart, skeletal muscle, pancreas, kidney, liver, lung, placenta and brain. Also expressed in testis and thymus.

Database cross-references

UniProt: P63279
Ensembl: ENST00000325437
Ensembl: ENST00000355803
Ensembl: ENST00000397514
Ensembl: ENST00000397515
Ensembl: ENST00000403747
Ensembl: ENST00000406620
Ensembl: ENST00000566587
MIM: 601661
neXtProt: NX_P63279
Antibodypedia: P63279 (may not find the protein thus also not any antibody)
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