UBE2A_HUMAN

Source: PM19886704
PM23856902
Marked as 'Non-membrane protein'
Confidence: low (only semi-automatic identification from reviews) Search PubMed for
(RBC AND this entry)
Gene names: UBE2A , RAD6A
Protein names and data: UBE2A_HUMAN , Ubiquitin-conjugating enzyme E2 A; 6.3.2.19 , RAD6 homolog A; HR6A; hHR6A; Ubiquitin carrier protein A; Ubiquitin-protein ligase A Lenght: 152 a.a.
Mass: 17315 Da
fasta formatted sequence
Function: Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In association with the E3 enzyme BRE1 (RNF20 and/or RNF40), it plays a role in transcription regulation by catalyzing the monoubiquitination of histone H2B at 'Lys-120' to form H2BK120ub1. H2BK120ub1 gives a specific tag for epigenetic transcriptional activation, elongation by RNA polymerase II, telomeric silencing, and is also a prerequisite for H3K4me and H3K79me formation. In vitro catalyzes 'Lys-11', as well as 'Lys-48'-linked polyubiquitination. Required for postreplication repair of UV-damaged DNA.
Catalytic activity: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine.
Pathway: Protein modification; protein ubiquitination.
Disease:

Genetic variants

Database cross-references

UniProt: P49459
Ensembl: ENST00000346330
Ensembl: ENST00000371558
Ensembl: ENST00000371569
MIM: 300860
MIM: 312180
neXtProt: NX_P49459
Antibodypedia: P49459 (may not find the protein thus also not any antibody)
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