UBE3C_HUMAN

Source: PM19886704
PM23856902
Marked as 'Non-membrane protein'
Confidence: low (only semi-automatic identification from reviews) Search PubMed for
(RBC AND this entry)
Gene names: UBE3C , KIAA0010, KIAA10
Protein names and data: UBE3C_HUMAN , Ubiquitin-protein ligase E3C; 6.3.2.- , HectH2 Lenght: 1083 a.a.
Mass: 123923 Da
fasta formatted sequence
Function: E3 ubiquitin-protein ligase that accepts ubiquitin from the E2 ubiquitin-conjugating enzyme UBE2D1 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Can assemble unanchored poly-ubiquitin chains in either 'Lys-29'- or 'Lys-48'-linked polyubiquitin chains. Has preference for 'Lys-48' linkages. It can target itself for ubiquitination in vitro and may promote its own degradation in vivo.
Pathway: Protein modification; protein ubiquitination.
Cellular location: Nucleus (Potential).
Tissue specificity: Highly expressed in skeletal muscle. Detected at much lower levels in kidney and pancreas.

Database cross-references

UniProt: Q15386
Ensembl: ENST00000348165
Ensembl: ENST00000389103
MIM: 614454
neXtProt: NX_Q15386
Antibodypedia: Q15386 (may not find the protein thus also not any antibody)
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