UBP11_HUMAN

Source: PM19886704
PM23856902
Marked as 'Non-membrane protein'
Confidence: low (only semi-automatic identification from reviews) Search PubMed for
(RBC AND this entry)
Gene names: USP11 , UHX1
Protein names and data: UBP11_HUMAN , Ubiquitin carboxyl-terminal hydrolase 11; 3.4.19.12 , Deubiquitinating enzyme 11; Ubiquitin thioesterase 11; Ubiquitin-specific-processing protease 11 Lenght: 963 a.a.
Mass: 109817 Da
fasta formatted sequence
Function: Protease that can remove conjugated ubiquitin from target proteins and polyubiquitin chains. Inhibits the degradation of target proteins by the proteasome. Plays a role in the regulation of pathways leading to NF-kappa-B activation. Plays a role in the regulation of DNA repair after double-stranded DNA breaks.
Catalytic activity: Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C- terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).
Cellular location: Nucleus. Cytoplasm. Note=Predominantly nuclear. Associates with chromatin.

Database cross-references

UniProt: P51784
Ensembl: ENST00000218348
MIM: 300050
neXtProt: NX_P51784
Antibodypedia: P51784 (may not find the protein thus also not any antibody)
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