UBP14_HUMAN

Source: hRBCD ; ID: IPI00219913
PM19886704
PM23856902
PM22954596
Marked as 'Membrane associated protein'
Confidence: high (present in two of the MS resources) Search PubMed for
(RBC AND this entry)
Gene names: USP14 , TGT
Protein names and data: UBP14_HUMAN , Ubiquitin carboxyl-terminal hydrolase 14; 3.4.19.12 , Deubiquitinating enzyme 14; Ubiquitin thioesterase 14; Ubiquitin-specific-processing protease 14 Lenght: 494 a.a.
Mass: 56069 Da
fasta formatted sequence
Function: Proteasome-associated deubiquitinase which releases ubiquitin from the proteasome targeted ubiquitinated proteins. Ensures the regeneration of ubiquitin at the proteasome. Is a reversibly associated subunit of the proteasome and a large fraction of proteasome-free protein exists within the cell. Required for the degradation of the chemokine receptor CXCR4 which is critical for CXCL12-induced cell chemotaxis. Serves also as a physiological inhibitor of endoplasmic reticulum-associated degradation (ERAD) under the non-stressed condition by inhibiting the degradation of unfolded endoplasmic reticulum proteins via interaction with ERN1. Indispensable for synaptic development and function at neuromuscular junctions (NMJs).
Catalytic activity: Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C- terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).
Cellular location: Cytoplasm. Cell membrane; Peripheral membrane protein.

Database cross-references

UniProt: P54578
Ensembl: ENST00000261601
Ensembl: ENST00000582707
MIM: 607274
neXtProt: NX_P54578
Antibodypedia: P54578 (may not find the protein thus also not any antibody)
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