UBP19_HUMAN

Source: PM19886704
PM23856902
Marked as 'Integral membrane protein'
Confidence: low (only semi-automatic identification from reviews) Search PubMed for
(RBC AND this entry)
Gene names: USP19 , KIAA0891, ZMYND9
Protein names and data: UBP19_HUMAN , Ubiquitin carboxyl-terminal hydrolase 19; 3.4.19.12 , Deubiquitinating enzyme 19; Ubiquitin thioesterase 19; Ubiquitin-specific-processing protease 19; Zinc finger MYND domain-containing protein 9 Lenght: 1318 a.a.
Mass: 145651 Da
fasta formatted sequence
Function: Deubiquitinating enzyme that regulates the degradation of various proteins. Deubiquitinates and prevents proteasomal degradation of RNF123 which in turn stimulates CDKN1B ubiquitin- dependent degradation thereby playing a role in cell proliferation. Involved in decreased protein synthesis in atrophying skeletal muscle. Modulates transcription of major myofibrillar proteins. Also involved in turnover of endoplasmic- reticulum-associated degradation (ERAD) substrates. Regulates the stability of BIRC2/c-IAP1 and BIRC3/c-IAP2 by preventing their ubiquitination. Required for cells to mount an appropriate response to hypoxia and rescues HIF1A from degradation in a non- catalytic manner. Plays an important role in 17 beta-estradiol (E2)-inhibited myogenesis. Decreases the levels of ubiquitinated proteins during skeletal muscle formation and acts to repress myogenesis. Exhibits a preference towards 'Lys-63'-linked Ubiquitin chains.
Catalytic activity: Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C- terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).
Cellular location: Endoplasmic reticulum membrane; Single-pass membrane protein.

Genetic variants

Database cross-references

UniProt: O94966
Ensembl: ENST00000398888
Ensembl: ENST00000417901
Ensembl: ENST00000434032
Ensembl: ENST00000453664
MIM: 614471
neXtProt: NX_O94966
Antibodypedia: O94966 (may not find the protein thus also not any antibody)
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