UBP47_HUMAN

Source: PM19886704
PM23856902
Marked as 'Non-membrane protein'
Confidence: low (only semi-automatic identification from reviews) Search PubMed for
(RBC AND this entry)
Gene names: USP47
Protein names and data: UBP47_HUMAN , Ubiquitin carboxyl-terminal hydrolase 47; 3.4.19.12 , Deubiquitinating enzyme 47; Ubiquitin thioesterase 47; Ubiquitin-specific-processing protease 47 Lenght: 1375 a.a.
Mass: 157311 Da
fasta formatted sequence
Function: Ubiquitin-specific protease that specifically deubiquitinates monoubiquitinated DNA polymerase beta (POLB), stabilizing POLB thereby playing a role in base-excision repair (BER). Acts as a regulator of cell growth and genome integrity. May also indirectly regulates CDC25A expression at a transcriptional level.
Catalytic activity: Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C- terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).
Cellular location: Cytoplasm.
Tissue specificity: Expressed in skeletal muscle, heart and testis.

Genetic variants

Database cross-references

UniProt: Q96K76
Ensembl: ENST00000339865
Ensembl: ENST00000399455
Ensembl: ENST00000539466
MIM: 614460
neXtProt: NX_Q96K76
Antibodypedia: Q96K76 (may not find the protein thus also not any antibody)
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