UBP4_HUMAN

Source: PM19886704
PM23856902
Marked as 'Non-membrane protein'
Confidence: low (only semi-automatic identification from reviews) Search PubMed for
(RBC AND this entry)
Gene names: USP4 , UNP, UNPH
Protein names and data: UBP4_HUMAN , Ubiquitin carboxyl-terminal hydrolase 4; 3.4.19.12 , Deubiquitinating enzyme 4; Ubiquitin thioesterase 4; Ubiquitin-specific-processing protease 4; Ubiquitous nuclear protein homolog Lenght: 963 a.a.
Mass: 108565 Da
fasta formatted sequence
Function: Hydrolase that deubiquitinates target proteins such as the receptor ADORA2A, PDPK1 and TRIM21. Deubiquitination of ADORA2A increases the amount of functional receptor at the cell surface. Plays a role in the regulation of quality control in the ER.
Catalytic activity: Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C- terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).
Cellular location: Cytoplasm (By similarity). Nucleus (By similarity). Note=Shuttles between the nucleus and cytoplasm. Exported to the cytoplasm in a CRM1-dependent manner and recycled back to the nucleus via the importin alpha/beta heterodimeric import receptor. The relative amounts found in the nucleus and cytoplasm vary according to the cell type (By similarity).
Tissue specificity: Overexpressed in small cell tumors and adenocarcinomas of the lung compared to wild-type lung (at protein level). Expressed in the hippocampal neurons.

Genetic variants

Database cross-references

UniProt: Q13107
Ensembl: ENST00000265560
Ensembl: ENST00000351842
Ensembl: ENST00000416417
MIM: 603486
neXtProt: NX_Q13107
Antibodypedia: Q13107 (may not find the protein thus also not any antibody)
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