UBP5_HUMAN

Source: hRBCD ; ID: IPI00024664
PM19886704
PM23856902
PM22954596
Marked as 'Non-membrane protein'
Confidence: high (present in two of the MS resources) Search PubMed for
(RBC AND this entry)
Gene names: USP5 , ISOT
Protein names and data: UBP5_HUMAN , Ubiquitin carboxyl-terminal hydrolase 5; 3.4.19.12 , Deubiquitinating enzyme 5; Isopeptidase T; Ubiquitin thioesterase 5; Ubiquitin-specific-processing protease 5 Lenght: 858 a.a.
Mass: 95786 Da
fasta formatted sequence
Function: Cleaves linear and branched multiubiquitin polymers with a marked preference for branched polymers. Involved in unanchored 'Lys-48'-linked polyubiquitin disassembly. Binds linear and 'Lys- 63'-linked polyubiquitin with a lower affinity. Knock-down of USP5 causes the accumulation of p53/TP53 and an increase in p53/TP53 transcriptional activity because the unanchored polyubiquitin that accumulates is able to compete with ubiquitinated p53/TP53 but not with MDM2 for proteasomal recognition.
Catalytic activity: Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C- terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Database cross-references

UniProt: P45974
Ensembl: ENST00000229268
Ensembl: ENST00000389231
Ensembl: ENST00000595281
Ensembl: ENST00000597018
MIM: 601447
neXtProt: NX_P45974
Antibodypedia: P45974 (may not find the protein thus also not any antibody)
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